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Additionally, developing caffeine analogs or derivatives that preferentially modulate IP3Rs without over-activating RyRs could provide a more targeted approach to mitigate calcium dysregulation in AD

Granitzer S, Ellinger I, Khan R et al (2020) In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta